SECTION EDITOR: HASSAN M. FATHALLAH-SHAYKH, MD Functional Genomics, Fragile X Syndrome, and RNA Interference

SECTION EDITOR: HASSAN M. FATHALLAH-SHAYKH, MD Brain Development in Healthy, Hyperactive, and Psychotic Children

S erious and chronic childhood psychiatric disorders have long been assumed to reflect relatively subtle abnormalities of brain development. Although diagnostic brain imaging is well established in pediatric neurology, it has not yet permitted quantitative assessment of brain abnormalities in children with psychiatric illnesses. Recent advances in brain magnetic resonance imaging (MRI) allow re...

Anti-Angiogenesis, Gene Therapy, and Immunotherapy in Malignant Gliomas

c-Src and Neural Wiskott-Aldrich Syndrome Protein (N-WASP) Promote Low Oxygen-Induced Accelerated Brain Invasion by Gliomas

Malignant gliomas remain associated with poor prognosis and high morbidity because of their ability to invade the brain; furthermore, human gliomas exhibit a phenotype of accelerated brain invasion in response to anti-angiogenic drugs. Here, we study 8 human glioblastoma cell lines; U251, U87, D54 and LN229 show accelerated motility in low ambient oxygen. Src inhibition by Dasatinib abrogates t...

Proper orthogonal decomposition for parameter estimation in oscillating biological networks

Functional genomics, fragile X syndrome, and RNA interference.

A remarkable revolution is occurring in biomedical science that is likely to have profound implications for the way we treat human diseases in the future. In the past 2 years, we have learned that introduction of short double-stranded RNA (dsRNA) molecules into vertebrate cells can silence any gene homologous to the dsRNA. This process is called RNA interference (RNAi) and is based on the abili...